NMR Spectroscopy Of Intact Body, Heterogeneous System

Advanced nuclear magnetic resonance (NMR) spectroscopy pulse sequence editing enables noninvasive assessment of the spatial distribution of chemical composition and diffusion behavior of materials. However, the spectral resolution and analytical approach for heterogeneous materials could still be improved.

Here, scientists create tools for thoroughly analyzing substances and their dynamics in whole bodies and heterogeneous systems using information from NMR spectroscopy, such as spatial z-position, chemical shift, diffusion, and relaxation. “spatially molecular-dynamically ordered spectroscopy” refers to this operation as a whole. (SMOOSY). To assess this technique, pseudo-three-dimensional (3D) SMOOSY spectra of an intact shrimp and two heterogeneous systems are taken.

Using a pseudo-spectral imaging technique and the SMOOSY processor, two-dimensional (2D) chemical shift imaging spectra are used to plot dynamics information. The various dynamics of the compounds at each spatial z-position of the shrimp’s body and two heterogeneous systems can be non-invasively evaluated using pseudo-2D SMOOSY spectral images.

Nuclear magnetic resonance (NMR), magnetic resonance imaging (MRI), and magnetic resonance spectroscopy (MRS) have a very wide variety of applications in comparison to other analytical techniques. Solution-state NMR is particularly helpful for analyzing compositions and determining molecular structure. The comprehensive compositional analysis is important for metabolomics and synthetic and natural product chemistry, where it is used to assess the characteristics of complicated samples or mixtures and their differences.

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