Biomechanics – Drug Response In Hypoxia - Spectroscopy

Researchers report alteration of cancer cells’ biomechanics and biophysical properties induced by the standard chemotherapeutic drugs using atomic force microscopy-based, time-traced imaging and force spectroscopy measurements. The researchers provide new information about the interplay between hypoxia and chemotherapeutic drugs. Stiffness kinetics depends on type of the drug, exposure time to the drug, and oxygen levels [..]

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Uveal Melanoma – New Promising Treatment

The fatality rate for uveal melanoma, a rare and dangerous disease of the eye, has remained unchanged for the past 40 years. New treatments to preserve eyesight and avoid mortality are urgently needed because half of the melanomas spread to other body organs, resulting in death in less than a year. Researchers have discovered a [..]

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Semiconductors, Integrated Photonics, And Moore’s Law

Photonics integration is gaining pace in semiconductors, particularly in heterogeneous multi-die packages, as chipmakers look for innovative solutions to overcome power constraints and deal with growing data volumes. Since the end of Dennard scaling, which occurred at the 90nm node, power has become increasingly challenging. There are more transistors per mm2, and the wires are [..]

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Wide-Field Imaging - De-Scattering TFM Images

Researchers have devised a new computational de-scattering approach termed de-scattering with excitation patterning in temporal focusing microscopy (DEEP-TFM). They employed two-photon patterned excitation with wide-field temporal focusing, but the signal was detected using a wide-field imaging detector. They created a modified temporal focusing microscope that uses a digital micromirror device to transmit arbitrary excitation patterns [..]

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Computer Chips - IR Cameras, AI Predict Boiling Crisis

Boiling is a complicated physical phenomenon involving at least two phases of matter. Many factors contribute to the system. Liquid to gas conversion takes energy from heated surfaces, preventing overheating in everything from nuclear power plants to powerful computer chips. However, if surfaces become too heated, they may undergo a boiling crisis. Bubbles form quickly [..]

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Telecom Wavelength Optoelectronics

Scientists have developed the first room-temperature, electrically driven, topological laser, which could be useful in telecom wavelength applications. The novel device is made up of a 10 by 10 grid of 30 micron-wide rings. Small oblong rings around 5 microns wide connect these rings to one another. All these rings consist of a sandwich of [..]

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Wearable Sensor

A new wearable sensor can measure tissue oxygenation through the skin. A 3D-printed housing, a sensor head, and an adhesive oxygen sensing film make up the device. Electronic components process the sensor data and communicate via Bluetooth or Wi-Fi. The sensor detects the phosphorescence lifetime and intensity of the acrylic oxygen sensing film. Two LEDs [..]

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Lung Tumor Detection – IR Imaging, Machine Learning

Depending on the type of lung cancer, the prognosis and successful treatments differ. While it previously took several days to precisely determine the underlying lung tumor mutation, a research team has been able to reliably perform this determination in just one step. They used a combination of quantum cascade laser-based infrared microscopy and machine learning. [..]

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Kirigami Design – Curvy Camera For Night Vision

Researchers have developed a camera with a curvy, adaptable imaging sensor that could improve image quality in endoscopes, night-vision goggles, artificial compound eyes, and fish-eye cameras. They designed the camera using Kirigami, the Japanese art of paper cutting. Existing curvy imagers are flexible but not compatible with tunable focal surfaces or stretchable but having low [..]

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MRI Reconstruction - Deep Learning

Researchers have developed a deep learning platform to speed up the MRI reconstruction process. The framework takes a fraction of the measurements that the traditional technique would use. It uses plug-and-play algorithms to combine physics-driven data acquisition models with state-of-the-art learned image models. The plug-and-play techniques recover pictures faster, with improved quality and potentially superior [..]

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Nanocrystals – Layered Metasurfaces For Infrared Imaging

Infrared imaging applications are growing from food quality control and remote sensing to night vision devices and LiDAR. IR cameras convert infrared light to electrons and project the resultant image on a display. However, such cameras are bulky, disrupt normal vision, and require low temperature. Alternatively, a nonlinear optical process – nonlinear sum-frequency generation (SFG) [..]

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Spectroscopic Measurements – New High-Speed Method

Researchers have discovered a new method for faster spectroscopic measurements. They observed changes in the light spectrum by using simple, rapid polarization measurements by linking polarization to the color of a pulsed laser. The technique opens up new possibilities for measuring spectral changes over the complete color spectrum of light on a nanosecond time frame. [..]

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Inversion Symmetry Broken For Efficient Optoelectronic Materials

Light-emitting, energy-harvesting, and sensing technologies could all benefit from optoelectronic materials that can convert light energy into electricity and electricity into light. However, devices leveraging these materials are notoriously inefficient, wasting a considerable amount of valuable energy in the form of heat. New light-electricity conversion principles can break the present efficiency restrictions. Inversion symmetry is [..]

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Atomic Force Microscopy - Computational Method Achieves Super Resolution

A new computational method dramatically increases the resolution of atomic force microscopy. Under standard physiological settings, the approach exposes atomic-level data on proteins and other biological structures. It gives up a whole new world of possibilities in cell biology, virology, and other microscopic processes. In physics, atomic force microscopy can efficiently resolve atoms on solid [..]

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Cancer Immunotherapy Screening - Droplet Microfluidics

Cancer immunotherapy has brought a paradigm shift in cancer treatment. It uses the immune system’s strength to treat cancers. However, next-generation cancer immunotherapies have yet to reach their full potential. Poor throughput of functional screens that can only evaluate a few thousand antibodies is a limitation. Droplet microfluidic technology enables exceptional throughput in cell research [..]

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Early Detection Of Brain Disorders - New Imaging Method

New imaging technology may lead to early detection of neurological illnesses such as Alzheimer’s disease, allowing doctors to diagnose and treat patients more swiftly. The super-resolution imaging technique combines position emission tomography (PET) with an external motion-tracking device to provide incredibly detailed brain images. The patient’s undesired movements frequently hamper the quality of brain PET [..]

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Spaceplate For Ultra-Thin Imaging Systems

All imaging systems consist of two main components: lenses and the spaces between them. The distances between lenses are just as critical to image formation as the lenses themselves. They can easily be greater than the summed thicknesses of the lenses. Now researchers have developed an optic called spaceplate to address this dominant contribution to [..]

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