Researchers have developed and tested a new blood vessel imaging approach that will accelerate imaging-based research in the lab by allowing investigators to capture images of blood vessels at different spatial scales.
Tested in mouse tissues, the method, dubbed “VascuViz,” includes a quick-setting polymer mixture to fill blood vessels and make them visible in multiple imaging techniques. The blood vessel imaging approach enables researchers to visualize the structure of a tissue’s vasculature, which in conjunction with detailed mathematical models or complementary images of other tissue elements can clarify the complex role of blood flow in health and disease.
The combined images of the blood vessels should not only enhance the study of the biology of diseases that involve abnormalities in blood flow, such as cancer and stroke, but also advance the understanding of the structures and functions of tissues throughout the body.
The development of VascuViz is particularly useful in creating computerized visualizations of how complex biological systems such as the circulatory system work, and is a hallmark of the growing field of “image-based” vascular systems biology.