Blood Biomarkers, Genomics Better Predict Disease Risk

According to studies, blood biomarkers can enhance risk prediction for twelve illnesses over utilizing genetics alone. The study shows that ‘metabolomic’ risk scores created from these blood markers are often better disease risk indicators than genetic data alone. The study used over 200 biomarkers gathered from around half a million people across three large-scale biobanks. Although the findings have not yet undergone peer review, they might significantly advance preventative healthcare.

Genetics and biomarkers were shown to be equally beneficial in predicting illness risk even ten years later for all disorders. And in almost all instances, the blood biomarkers offered a greater prediction.

Finding patients most at risk of contracting a disease is one of the biggest issues in preventative medicine. Polygenic risk scores, genetic forecasts derived from whole genome investigations, have recently attracted attention. However, due to difficulty with clinical application, its wider usage has encountered real-world obstacles.

The researchers developed statistical models using these biomarkers, which can be easily obtained from blood samples, to forecast a person’s future risks for the diseases that the World Health Organization considers to be the major causes of disability-adjusted life years in high-income nations. The researchers demonstrated that incorporating blood biomarkers with this information consistently improved risk prediction for the illnesses for which polygenic risk scores were available.

This indicates that it is generally simple to identify the people who are most at risk for certain diseases and provide them with measures to lower their risk, keeping them healthy and, at the same time, lowering the financial load on healthcare systems.

Read more

Related Content: Technique Enables Noninvasive Imaging Of Delicate Organs