By combining expertise in photonics – manipulating light beams in nanoscale waveguides on a chip – and materials science, Cornell researchers have laid the groundwork for a chemical sensor on a chip that could be used in small portable devices to analyze samples in a lab, monitor air and water quality in the field and [..]

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Today, patients with cataracts can choose from several types of artificial lenses, which are surgically implanted in the eye to replace cloudy lenses that obstruct vision. A new vision simulator could help these patients see how the world would look with each type of implanted artificial lens, before they have surgery. Read more

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Live 3-D imaging is one of the hottest topics in optics today, transforming medical imaging capabilities and delivering the immersive experience behind augmented and virtual reality. During The Optical Society’s Light the Future centennial program in Heidelberg, Germany on 26 July, Dr. Joseph Izatt of Duke University and Microsoft’s Bernard Kress gave an insider’s look [..]

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For medics on the battlefield and doctors in remote or developing parts of the world, getting rapid access to the drugs needed to treat patients can be challenging. Biopharmaceutical drugs, which are used in a wide range of therapies including vaccines and treatments for diabetes and cancer, are typically produced in large, centralized fermentation plants. [..]

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It is hard to overestimate the impact fluorescence imaging has had on life sciences. Fluorescence has advanced the field dramatically, and has become the basis for numerous bioimaging approaches and applications. Optical filtering provides a major source of enhancement for fluorescence techniques —enabling image contrast maximization, maintenance of image quality, and delivery of better outcomes. [..]

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MIT researchers have developed a new technique for imaging brain tissue at multiple scales, allowing them to peer at molecules within cells or take a wider view of the long-range connections between neurons. This technique, known as magnified analysis of proteome (MAP), should help scientists in their ongoing efforts to chart the connectivity and functions [..]

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Learning how to look inside a body without having to cut it open is still an important part of medical research. One of the great challenges in imaging remains the visualization of oxygen in tissue. A team led by Prof. Vasilis Ntziachristos, Chair for Biological Imaging at the Technical University of Munich (TUM) and Director [..]

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Researchers from the University of North Carolina – Chapel Hill (UNC-Chapel Hill) and North Carolina State University (NC State; Raleigh, NC) built on an existing technology — two-photon microscopy — to allow neuroscientists to capture images of the brain almost 10 times larger than previously possible, therefore helping them to better understand the behavior of [..]

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With the goal of creating a technology that will allow doctors to deliver life-saving laser treatments to patients with brain disorders, researchers at the University of California Riverside (UCR; Riverside, CA) have developed a transparent skull implant out of a biocompatible ceramic material. Read more

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To diagnose and assess diseases such as cancer, physicians typically make decisions based on averaged measurements taken from thousands of cells obtained in tissue biopsies. This approach works perfectly for some diseases, but when searching for one ‘bad apple’ amongst thousands of healthy neighbors, or if a disease mutates and changes as it grows, vital [..]

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Diabetes is one of the most prevalent chronic diseases, affecting approximately 9% of the global population. Because diabetes can cause many complications that dramatically increase the risk of death, such as cardiovascular, kidney, and neurological diseases, precise monitoring and continuous treatment are greatly needed. Read more

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Researchers at the Leiden University Medical Center (Netherlands) and collaborators developed a tumor-specific fluorescent agent and imaging system that could guide surgeons in real time to remove additional tumors in ovarian cancer patients that were not visible without fluorescence or could not be felt during surgery. Read more

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A surgical site infection (SSI) by drug-resistant “super bugs” can double a patient’s mortality rate. Germicidal UV lamps can kill these bacteria, but their broad wavelength spectrum is hazardous to the patient as well as the health care provider. Researchers at the Center for Radiological Research at Columbia University Medical Center (USA)… Read more

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A novel fusion-imaging technique uses magnetic resonance imaging (MRI) to guide the insertion of a laser fiber into a cancerous tumor. The laser, once inserted, applies heat to the cancerous tissue, destroying it. This technique, known as MRI-guided focal laser ablation, could improve treatment options and outcomes for men with prostate cancer. Read more

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Transparent objects, such as live biological cells, are difficult to observe and quantify using traditional light microscopes owing to lack of contrast. However, recent advances in quantitative phase imaging (QPI) of transparent microscopic specimens using digital holographic microscopy (DHM) have facilitated observation of unstained living cells in ways that were previously impossible. Read more

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A team of researchers at the University of Maryland (College Park, MD) and Harvard Medical School (Cambridge, MA) has developed a novel spectroscopy configuration that can obtain a biological sample’s entire Brillouin spectrum in one shot, saving time and allowing for noninvasive biological characterization in, say, potentially cancerous tumors. Read more

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Researchers from the National Physical Laboratory (NPL; Teddington, Middlesex, England) and MedImmune (Gaithersburg, MD), the global biologics research and development arm of Astra Zeneca, are collaborating to investigate, with super-resolution microscopy, the use of exosomes for targeted delivery of therapeutics. Read more

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