2D Nanomaterials

Two-dimensional (2D) nanomaterials have been made by dissolving layered materials in liquids, according to new UCL-led research. The liquids can be used to apply the 2D nanomaterials over large areas and at low costs, enabling a variety of important future applications. 2D nanomaterials, such as graphene, have the potential to revolutionise technology through their remarkable [..]

Read More

For scientists developing life-saving medicines, knowing how cells interact and communicate with one another is an important part of the puzzle. The problem is, being able to see those interactions through a microscope hasn’t always been possible. But now, thanks to University of New Mexico Associate Professor Keith Lidke, a new technique has opened the [..]

Read More

Optical microscopy experts at Colorado State University are once again pushing the envelope of biological imaging. Jeffrey Field, a research scientist in electrical engineering and director of CSU’s Microscope Imaging Network, has designed and built a fluorescence-detection microscope that combines three-dimensional and high-resolution image processing that’s also faster than comparable techniques. Read more

Read More

Optical imaging of large distributed neural populations is a key goal in revealing the principles underlying brain activity, with recent advances in single and multi-photon light-sheet microscopy and related techniques playing a significant role. Read more

Read More

Traditionally, the study of diseases at the molecular level has required scientists to extract cells and tissues from animal models and then look for clues in the samples that can determine the mechanisms underlying the disease and driving its progression. According to Chris B. Schaffer, associate professor of biomedical engineering at Cornell University, New York, [..]

Read More
Thermal Noise Imaging

Imagine standing in a dark room in which a single, glowing ball is bouncing around. The ball avoids a region in the center of the room. Over time, you might conclude that an object sits in that region, even though you cannot see it. That thought experiment illustrates thermal-noise imaging, a technique that a team [..]

Read More

A portable microscope, developed as part of a scalable, point-of-care, label-free microarray platform, may offer more rapid detection of sepsis and other infections caused by bacteria, ultimately saving millions of lives each year. The device combines photonics technology, microfluidics and molecular biology to produce sample-to-result processing up to 50 times faster than current testing techniques.. [..]

Read More

A research team from the United States and China has demonstrated a three-lens fluorescence microscopy method, paired with a computational algorithm, that uses “lost” light from biological specimens to produce high-resolution 3-D images. Read more

Read More

It is hard to overestimate the impact fluorescence imaging has had on life sciences. Fluorescence has advanced the field dramatically, and has become the basis for numerous bioimaging approaches and applications. Optical filtering provides a major source of enhancement for fluorescence techniques —enabling image contrast maximization, maintenance of image quality, and delivery of better outcomes. [..]

Read More

MIT researchers have developed a new technique for imaging brain tissue at multiple scales, allowing them to peer at molecules within cells or take a wider view of the long-range connections between neurons. This technique, known as magnified analysis of proteome (MAP), should help scientists in their ongoing efforts to chart the connectivity and functions [..]

Read More

Researchers from the University of North Carolina – Chapel Hill (UNC-Chapel Hill) and North Carolina State University (NC State; Raleigh, NC) built on an existing technology — two-photon microscopy — to allow neuroscientists to capture images of the brain almost 10 times larger than previously possible, therefore helping them to better understand the behavior of [..]

Read More

Cells contain thousands of messenger RNA molecules, which carry copies of DNA’s genetic instructions to the rest of the cell. MIT engineers have now developed a way to visualize these molecules in higher resolution than previously possible in intact tissues, allowing researchers to precisely map the location of RNA throughout cells. Read more

Read More

By using a light-sheet microscopy method, researchers at North Carolina State University discovered that therapeutic stem cells exit the bloodstream in a different manner than previously understood. This process, dubbed angiopellosis by the researchers, has implications for improving our understanding of not only intravenous stem cell therapies, but also metastatic cancers. Read more

Read More

Researchers at the Leiden University Medical Center (Netherlands) and collaborators developed a tumor-specific fluorescent agent and imaging system that could guide surgeons in real time to remove additional tumors in ovarian cancer patients that were not visible without fluorescence or could not be felt during surgery. Read more

Read More

Super-resolution microscopy is a valuable tool for biological imaging, and most techniques require fluorescent molecules to “break” the diffraction limit in order to view structures smaller than a wavelength of light. This fluorescence, however, prevents further imaging of the sample using certain contrast mechanisms such as harmonic generation. Read more

Read More

Transparent objects, such as live biological cells, are difficult to observe and quantify using traditional light microscopes owing to lack of contrast. However, recent advances in quantitative phase imaging (QPI) of transparent microscopic specimens using digital holographic microscopy (DHM) have facilitated observation of unstained living cells in ways that were previously impossible. Read more

Read More

Researchers from the National Physical Laboratory (NPL; Teddington, Middlesex, England) and MedImmune (Gaithersburg, MD), the global biologics research and development arm of Astra Zeneca, are collaborating to investigate, with super-resolution microscopy, the use of exosomes for targeted delivery of therapeutics. Read more

Read More