U.S. researchers, led by Vanderbilt University’s Anita Mahadevan-Jansen, hope to improve the detection and classification of inflammatory bowel disease (IBD) with their new compact Raman spectroscopy probe—which is coupled to an endoscope that’s commonly used during colonoscopy exams. Read more

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A little biosensor can analyze if there are antibiotics in your blood in 10 minutes. Developed by researchers from the University of Freiburg, the system could be used to develop a personalized course of antibiotics, but also to test food and water. The objective? Slow down the rise of multi-resistant bacteria. Read more

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Optical microscopy experts at Colorado State University are once again pushing the envelope of biological imaging. Jeffrey Field, a research scientist in electrical engineering and director of CSU’s Microscope Imaging Network, has designed and built a fluorescence-detection microscope that combines three-dimensional and high-resolution image processing that’s also faster than comparable techniques. Read more

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Optical imaging of large distributed neural populations is a key goal in revealing the principles underlying brain activity, with recent advances in single and multi-photon light-sheet microscopy and related techniques playing a significant role. Read more

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Thermo Action

Researchers at MIT and elsewhere have developed a new way of driving fluid droplets across surfaces in a precisely controlled way. The method could open up new possibilities for highly adaptable microfluidic devices, as well as for de-icing technologies, self-cleaning surfaces, and highly efficient condensers. Read more

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A quantitative phase spectroscopy (QPS) system that incorporates digital holography has been used to spot malaria-infected cells from a simple, untouched blood sample without any help from a human. The technique employs machine learning algorithms and has been shown accurate in detecting malaria infection 97 to 100 percent of the time. The research could form [..]

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MIT researchers have developed a technique for recovering visual information from light that has scattered because of interactions with the environment — such as passing through human tissue. The technique could lead to medical-imaging systems that use visible light, which carries much more information than X-rays or ultrasound waves, or to computer vision systems that [..]

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A contact lens-based system that uses a strategically placed drug polymer film to deliver medication gradually to the eye was shown to be as effective as daily eye drops in a preclinical model for managing glaucoma. In a study supported by a grant from the Boston Children’s Hospital, the effect of the drug-eluting contact lens [..]

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Qualifications

Cardiac arrhythmia — a wildly irregular heartbeat, can kill a person in minutes. Implantable defibrillators can provide lifesaving electrical jolts to the hearts of patients with a known risk of arrhythmia, but these shocks can be painful. Research teams in Germany and the United States have developed a potentially gentler method of stimulating a regular [..]

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Traditionally, the study of diseases at the molecular level has required scientists to extract cells and tissues from animal models and then look for clues in the samples that can determine the mechanisms underlying the disease and driving its progression. According to Chris B. Schaffer, associate professor of biomedical engineering at Cornell University, New York, [..]

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Researchers at the University of Michigan (Ann Arbor, MI) have developed a new technique that combines laser light with an FDA-approved green fluorescent dye to monitor cell structure and activity at the molecular level. The work could someday improve clinical imaging and better monitor tumors and other cell structures, as well as be used during [..]

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The genome-editing system known as CRISPR allows scientists to delete or replace any target gene in a living cell. MIT researchers have now added an extra layer of control over when and where this gene editing occurs, by making the system responsive to light. Read more

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Live 3D imaging is one of the hottest topics in optics today, transforming medical imaging capabilities and delivering the immersive experience behind augmented and virtual reality. During The Optical Society’s Light the Future Centennial program in Heidelberg, Germany on 26 July, Dr. Joseph Izatt of Duke University and Microsoft’s Bernard Kress gave an insider’s look [..]

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A portable microscope, developed as part of a scalable, point-of-care, label-free microarray platform, may offer more rapid detection of sepsis and other infections caused by bacteria, ultimately saving millions of lives each year. The device combines photonics technology, microfluidics and molecular biology to produce sample-to-result processing up to 50 times faster than current testing techniques.. [..]

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A research team from the United States and China has demonstrated a three-lens fluorescence microscopy method, paired with a computational algorithm, that uses “lost” light from biological specimens to produce high-resolution 3-D images. Read more

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By combining expertise in photonics – manipulating light beams in nanoscale waveguides on a chip – and materials science, Cornell researchers have laid the groundwork for a chemical sensor on a chip that could be used in small portable devices to analyze samples in a lab, monitor air and water quality in the field and [..]

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Today, patients with cataracts can choose from several types of artificial lenses, which are surgically implanted in the eye to replace cloudy lenses that obstruct vision. A new vision simulator could help these patients see how the world would look with each type of implanted artificial lens, before they have surgery. Read more

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