Optical microscopy experts at Colorado State University are once again pushing the envelope of biological imaging. Jeffrey Field, a research scientist in electrical engineering and director of CSU’s Microscope Imaging Network, has designed and built a fluorescence-detection microscope that combines three-dimensional and high-resolution image processing that’s also faster than comparable techniques. Read more

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Optical imaging of large distributed neural populations is a key goal in revealing the principles underlying brain activity, with recent advances in single and multi-photon light-sheet microscopy and related techniques playing a significant role. Read more

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A quantitative phase spectroscopy (QPS) system that incorporates digital holography has been used to spot malaria-infected cells from a simple, untouched blood sample without any help from a human. The technique employs machine learning algorithms and has been shown accurate in detecting malaria infection 97 to 100 percent of the time. The research could form [..]

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MIT researchers have developed a technique for recovering visual information from light that has scattered because of interactions with the environment — such as passing through human tissue. The technique could lead to medical-imaging systems that use visible light, which carries much more information than X-rays or ultrasound waves, or to computer vision systems that [..]

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A contact lens-based system that uses a strategically placed drug polymer film to deliver medication gradually to the eye was shown to be as effective as daily eye drops in a preclinical model for managing glaucoma. In a study supported by a grant from the Boston Children’s Hospital, the effect of the drug-eluting contact lens [..]

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Qualifications

Cardiac arrhythmia — a wildly irregular heartbeat, can kill a person in minutes. Implantable defibrillators can provide lifesaving electrical jolts to the hearts of patients with a known risk of arrhythmia, but these shocks can be painful. Research teams in Germany and the United States have developed a potentially gentler method of stimulating a regular [..]

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Traditionally, the study of diseases at the molecular level has required scientists to extract cells and tissues from animal models and then look for clues in the samples that can determine the mechanisms underlying the disease and driving its progression. According to Chris B. Schaffer, associate professor of biomedical engineering at Cornell University, New York, [..]

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Researchers at the University of Michigan (Ann Arbor, MI) have developed a new technique that combines laser light with an FDA-approved green fluorescent dye to monitor cell structure and activity at the molecular level. The work could someday improve clinical imaging and better monitor tumors and other cell structures, as well as be used during [..]

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Live 3D imaging is one of the hottest topics in optics today, transforming medical imaging capabilities and delivering the immersive experience behind augmented and virtual reality. During The Optical Society’s Light the Future Centennial program in Heidelberg, Germany on 26 July, Dr. Joseph Izatt of Duke University and Microsoft’s Bernard Kress gave an insider’s look [..]

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A portable microscope, developed as part of a scalable, point-of-care, label-free microarray platform, may offer more rapid detection of sepsis and other infections caused by bacteria, ultimately saving millions of lives each year. The device combines photonics technology, microfluidics and molecular biology to produce sample-to-result processing up to 50 times faster than current testing techniques.. [..]

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Today, patients with cataracts can choose from several types of artificial lenses, which are surgically implanted in the eye to replace cloudy lenses that obstruct vision. A new vision simulator could help these patients see how the world would look with each type of implanted artificial lens, before they have surgery. Read more

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For medics on the battlefield and doctors in remote or developing parts of the world, getting rapid access to the drugs needed to treat patients can be challenging. Biopharmaceutical drugs, which are used in a wide range of therapies including vaccines and treatments for diabetes and cancer, are typically produced in large, centralized fermentation plants. [..]

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Optical coherence tomography (OCT), adaptive optics and other technologies have opened up a world of possibilities for imaging the retina, right down to the photoreceptor cells (rods and cones) that are the gateway to vision. But the equipment for cellular-resolution imaging is bulky, heavy and inconvenient, making it all but useless for addressing one key [..]

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It is hard to overestimate the impact fluorescence imaging has had on life sciences. Fluorescence has advanced the field dramatically, and has become the basis for numerous bioimaging approaches and applications. Optical filtering provides a major source of enhancement for fluorescence techniques —enabling image contrast maximization, maintenance of image quality, and delivery of better outcomes. [..]

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MIT researchers have developed a new technique for imaging brain tissue at multiple scales, allowing them to peer at molecules within cells or take a wider view of the long-range connections between neurons. This technique, known as magnified analysis of proteome (MAP), should help scientists in their ongoing efforts to chart the connectivity and functions [..]

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Learning how to look inside a body without having to cut it open is still an important part of medical research. One of the great challenges in imaging remains the visualization of oxygen in tissue. A team led by Prof. Vasilis Ntziachristos, Chair for Biological Imaging at the Technical University of Munich (TUM) and Director [..]

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Researchers from the University of North Carolina – Chapel Hill (UNC-Chapel Hill) and North Carolina State University (NC State; Raleigh, NC) built on an existing technology — two-photon microscopy — to allow neuroscientists to capture images of the brain almost 10 times larger than previously possible, therefore helping them to better understand the behavior of [..]

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