For scientists developing life-saving medicines, knowing how cells interact and communicate with one another is an important part of the puzzle. The problem is, being able to see those interactions through a microscope hasn’t always been possible. But now, thanks to University of New Mexico Associate Professor Keith Lidke, a new technique has opened the [..]

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Optical microscopy experts at Colorado State University are once again pushing the envelope of biological imaging. Jeffrey Field, a research scientist in electrical engineering and director of CSU’s Microscope Imaging Network, has designed and built a fluorescence-detection microscope that combines three-dimensional and high-resolution image processing that’s also faster than comparable techniques. Read more

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Optical imaging of large distributed neural populations is a key goal in revealing the principles underlying brain activity, with recent advances in single and multi-photon light-sheet microscopy and related techniques playing a significant role. Read more

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A quantitative phase spectroscopy (QPS) system that incorporates digital holography has been used to spot malaria-infected cells from a simple, untouched blood sample without any help from a human. The technique employs machine learning algorithms and has been shown accurate in detecting malaria infection 97 to 100 percent of the time. The research could form [..]

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MIT researchers have developed a technique for recovering visual information from light that has scattered because of interactions with the environment — such as passing through human tissue. The technique could lead to medical-imaging systems that use visible light, which carries much more information than X-rays or ultrasound waves, or to computer vision systems that [..]

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Living Cells

Driven especially by advances in quantum cascade lasers (QCLs), infrared (IR) absorption spectroscopy has earned its stripes in recent years as a label-free technique for imaging a wide range of materials. Read more

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Traditionally, the study of diseases at the molecular level has required scientists to extract cells and tissues from animal models and then look for clues in the samples that can determine the mechanisms underlying the disease and driving its progression. According to Chris B. Schaffer, associate professor of biomedical engineering at Cornell University, New York, [..]

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Thermal Noise Imaging

Imagine standing in a dark room in which a single, glowing ball is bouncing around. The ball avoids a region in the center of the room. Over time, you might conclude that an object sits in that region, even though you cannot see it. That thought experiment illustrates thermal-noise imaging, a technique that a team [..]

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A portable microscope, developed as part of a scalable, point-of-care, label-free microarray platform, may offer more rapid detection of sepsis and other infections caused by bacteria, ultimately saving millions of lives each year. The device combines photonics technology, microfluidics and molecular biology to produce sample-to-result processing up to 50 times faster than current testing techniques.. [..]

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A research team from the United States and China has demonstrated a three-lens fluorescence microscopy method, paired with a computational algorithm, that uses “lost” light from biological specimens to produce high-resolution 3-D images. Read more

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Live 3-D imaging is one of the hottest topics in optics today, transforming medical imaging capabilities and delivering the immersive experience behind augmented and virtual reality. During The Optical Society’s Light the Future centennial program in Heidelberg, Germany on 26 July, Dr. Joseph Izatt of Duke University and Microsoft’s Bernard Kress gave an insider’s look [..]

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Optical coherence tomography (OCT), adaptive optics and other technologies have opened up a world of possibilities for imaging the retina, right down to the photoreceptor cells (rods and cones) that are the gateway to vision. But the equipment for cellular-resolution imaging is bulky, heavy and inconvenient, making it all but useless for addressing one key [..]

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It is hard to overestimate the impact fluorescence imaging has had on life sciences. Fluorescence has advanced the field dramatically, and has become the basis for numerous bioimaging approaches and applications. Optical filtering provides a major source of enhancement for fluorescence techniques —enabling image contrast maximization, maintenance of image quality, and delivery of better outcomes. [..]

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MIT researchers have developed a new technique for imaging brain tissue at multiple scales, allowing them to peer at molecules within cells or take a wider view of the long-range connections between neurons. This technique, known as magnified analysis of proteome (MAP), should help scientists in their ongoing efforts to chart the connectivity and functions [..]

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Learning how to look inside a body without having to cut it open is still an important part of medical research. One of the great challenges in imaging remains the visualization of oxygen in tissue. A team led by Prof. Vasilis Ntziachristos, Chair for Biological Imaging at the Technical University of Munich (TUM) and Director [..]

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Researchers from the University of North Carolina – Chapel Hill (UNC-Chapel Hill) and North Carolina State University (NC State; Raleigh, NC) built on an existing technology — two-photon microscopy — to allow neuroscientists to capture images of the brain almost 10 times larger than previously possible, therefore helping them to better understand the behavior of [..]

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With the goal of creating a technology that will allow doctors to deliver life-saving laser treatments to patients with brain disorders, researchers at the University of California Riverside (UCR; Riverside, CA) have developed a transparent skull implant out of a biocompatible ceramic material. Read more

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