Rapid-Live Screening Microscopy For Effective Cancer Treatment

Although chemotherapy is a highly effective cancer treatment, some cancer cells become resistant to it through a dormant phase known as senescence. These therapy-induced senescent (TIS) cells can develop resistance to treatment, even become aggressive, and spread. Early TIS cell detection may be essential to stopping their spread; however, the screening techniques must be more accurate and quicker. That could change with the development of researchers’ new, sophisticated rapid-live screening microscopy method, enabling medical professionals to recognize these cells early and modify treatment choices.

The work shows promise for revolutionizing research on anticancer treatments. Using this rapid-live screening microscopy method might assist medical professionals in making quicker, more informed treatment decisions.

The group saw and examined TIS cells in their native habitat by combining three state-of-the-art, label-free microscopy techniques: coherent Raman scattering, multi-photon absorption, and optical diffraction tomography. These cutting-edge instruments allowed the researchers to watch and analyze the cells’ form, structure, and physical and chemical properties throughout their existence, in contrast to traditional identification techniques. The fact that they carried out these studies without intrusive labeling is noteworthy as it guarantees the preservation of the cells’ original states.

The method demonstrated important alterations that take place in TIS cells. For instance, the mitochondria of the cells—the “powerhouses” that generate energy—rearranged themselves in a few days. In less than a day, the cells also started to overproduce lipids, which are fatty molecules, and they became bigger and flattened. Thanks to this study, the team created a precise timetable for the modifications’ development. The researchers believe that their new rapid-live screening microscopy tools will greatly enhance the future of cancer research.

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