Improved Diffuse Optical Tomography Allows Imaging Deeper Within The Brain

Functional near-IR imaging is an attractive route to neuroimaging and brain mapping, thanks to its ability to recover oxy- and deoxy-hemoglobin concentrations. But the inherently strong scattering of NIR wavelengths in tissues means that methods to boost image quality and quantitative accuracy are a necessary consideration.

A project from the University of Birmingham and Washington University in St. Louis has now demonstrated what it describes as “critical improvements to functional near-IR spectroscopy (fNIRS)-based optical imaging in the brain.” The work was published in Neurophotonics.

The advance hinges on enhancements to reconstructed image quality that become possible when phase shift measurements, which reflect the time-of-flight of the NIR light, are incorporated within the tomographic reconstruction.

Read more