FLASH-PAINT: Illuminating Cells

Scientists created a novel microscopy method called FLASH-PAINT, enabling researchers to see infinite distinct molecules inside a single cell. Imaging probes, also known as reagents, enable scientists to see minute features more clearly. Currently, imaging probes made of a single strand of DNA and a fluorescent dye are used in conjunction with an antibody to visualize internal cellular activities. This approach is constrained, though, because every target needs a different imaging probe.

The team has developed an adaptor that revolutionizes the field by linking any form of target to any probe. Due to its momentary binding to the target, this breakthrough technology enables super-resolution microscopy to be performed 100 times faster and for a tenth of the price of existing methods. This significant advancement could potentially expedite scientific discovery, allowing researchers to observe intricate subcellular processes that were previously unobservable. This, in turn, could equip medical professionals with more effective strategies to combat various illnesses, including cancer.

According to the team, the goal of FLASH-PAINT is to enable researchers to see intricate subcellular processes that were previously unavailable, which could aid medical professionals in learning more effective ways to treat various illnesses, including cancer. FLASH-PAINT use in tissue imaging and its potential as a diagnostic tool are being investigated further. 

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