Chip-Based Biosensor For Optofluidic Sensing Devices

Researchers have shown that chip-based biosensor devices that identify or evaluate chemicals have significantly improved. The accomplishments lay the foundation for highly sensitive portable integrated optofluidic sensing devices that could conduct different medical tests simultaneously, even if they involve very different bioparticles at different concentrations, like viral particles and DNA.

Researchers gave an optofluidic chip-based biosensor new signal-processing techniques. With the aid of these developments, a combination of nanobeads in concentrations spanning eight orders of magnitude, from attomolar to nanomolar, could be detected fluorescence in real-time. More than 10,000 times, this increases the concentration range where these sensors can function.

This research represents the most recent milestone in developing integrated optofluidic sensing systems, which can detect single biomolecules across a broad concentration range. They have demonstrated that this is possible using a single technique that enables the measurement and distinction of many particle kinds concurrently, even when they have extremely varying concentrations.

In the latest research, scientists created signal-processing techniques that simultaneously identify particles in high and low quantities, even when the amounts are unknown. To do this, they utilized two separate signal modulation frequencies: low-frequency laser modulation and high-frequency laser modulation, which allowed them to simultaneously detect huge signals from numerous particles at high concentrations and discriminate between single particles at low concentrations.

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