Multiphoton excitation (MPE) microscopy has evolved significantly over the past 30 years, becoming a powerful imaging method in various life sciences. Modern techniques include fluorescence microscopy, Raman scattering, and harmonic generation. MPE is used in neuroscience, pharmaceutical development, and preclinical research. The ultrafast laser is the critical component underpinning all MPE microscopy methods. Ultrafast laser [..]

AI machine vision is a technology that enables machines to analyze and comprehend visual data like humans do. It can do tasks including item detection, scene analysis, and autonomous navigation, revolutionizing industries that humans previously dominated. Manufacturing is one of the industries where artificial intelligence machine vision has had a significant impact, with a wide [..]

The pursuit of making everything smaller has led to significant progress in various fields, including micro-optics. Two-photon polymerization (TPP) 3D printing is an important manufacturing technique that enables these advancements. However, errors in the nanometer range can have significant consequences, making it essential to understand and compensate for systematic errors in the printing process. These [..]

Holograms provide a three-dimensional perspective of objects, creating a realistic and immersive experience. They have applications in medical imaging, manufacturing, and virtual reality. However, because of their computationally intensive nature and the requirement for a particular camera, their creation is difficult, and their broad application is limited. Many Deep Learning Approach for producing holograms have [..]

Following iDISCO+-based clearing and immunolabeling, researchers devised a protocol for the complete human eye’s light sheet fluorescence microscopy (LSFM). En-face observation of the fundus and resolution of retinal capillaries are made possible by this method’s ability to provide three-dimensional (3D) navigation and personalized presentation. This technique is helpful in anatomopathology and research because it gets [..]

Scientists have created plasmonic plastic, a 3D-printable composite material with special optical qualities. This research has produced 3D-printed optical hydrogen sensors, which may be crucial to the industrial and energy shift toward green energy. Over the past 20 years, there has been a sharp increase in interest in plasmonic metal nanoparticles and all of their [..]

Researchers have developed a nonrelativistic and nonmagnetic approach to generate Terahertz (THz) waves, which can be used to probe the magnetic properties of new materials. Researchers use the anisotropic electrical conductivity of particular materials to directly exploit laser-excited, high-density charge currents across nanoscale metallic surfaces to harness the power of these currents to generate THz [..]

Raman spectroscopy—a method of evaluating substances by shining monochromatic light over a sample and seeing the emerging dispersed light—has frustrated biologists for more than fifty years. During the optical measurements, the heat generated by the light nearly kills living proteins, leading to decreased and non-repeatable findings. It appears that these hassles may be the past [..]

By examining exhaled air, researchers have created a non-invasive breath analyzer method to monitor the development of tiny blood clots called immunothrombosis. Due to inflammation, immunothrombosis can lead to serious consequences in individuals with severe COVID-19 and exacerbate sepsis, heart disease, diabetes, and other illnesses. The researchers created a non-invasive breath analyzer method that uses [..]

Although chemotherapy is a highly effective cancer treatment, some cancer cells become resistant to it through a dormant phase known as senescence. These therapy-induced senescent (TIS) cells can develop resistance to treatment, even become aggressive, and spread. Early TIS cell detection may be essential to stopping their spread; however, the screening techniques must be more [..]

When added to silicate glass, niobium oxide (Nb2O5) causes silica network polymerization, raising bond density and connectivity and improving specialty glass’s mechanical and thermal durability. It is the first study to demonstrate this effect. The work integrated computational modeling with actual Raman and nuclear magnetic resonance spectroscopy findings. In addition to the previously reported findings, [..]

When it comes to high-capacity screening tests, or assays, for detecting and targeting certain cells or analytes (substances whose chemical makeup is the goal of identification), the static droplet array (SDA) is an essential and fundamental instrument. One significant technological barrier that prevents the SDA’s wider use is the extraction and collection of target droplets [..]

Virtually applying makeup before completing a purchase or having pterodactyls swoop above in a game are just two examples of how augmented reality and other immersive technologies are changing how we play, watch, and learn. Immersion displays would realize their full potential using low-cost, ultra-small light-emitting diodes (LEDs) or micro-LEDs. However, these LEDs still need [..]

The rapid expansion of artificial intelligence (AI) and machine learning (ML) applications requires effective connectivity between processing units and high-speed transmission. It has increased interest in optical interconnects, especially for short-range connections between XPUs (CPUs, GPUs, and memory). When compared to conventional methods, silicon photonics is showing promise as a technology for enhanced performance, cost-effectiveness, and [..]

Transmission electron microscopes use inline holography to measure and rectify images in real space and to measure magnetic and electric fields. On the other hand, it needs help with incoherent dispersion and low-spatial-frequency information transmission. This work optimizes reconstruction parameters and compares the outcomes using gradient flipping, phase prediction, and incoherent background removal. Transmission electron [..]

Artificial materials that are skilled at influencing perception are called metasurfaces. Metasurfaces are attracting much interest as optical components that enable the miniaturization of optical systems for the next generation of virtual and augmented reality and LiDAR. They enable lenses to be shrunk to one 10,000th the size of normal lenses. Countries may gain a considerable [..]

Researchers have demonstrated that chip-based optical frequency combs with sufficient output power for optical atomic clocks and other practical applications may be made using dissipative Kerr solitons (DKSs). The development could result in equipment built on chips that can do precise tests previously only achievable in a few specialist labs. In metrology, frequency combs are [..]

According to a new study, artificial intelligence can forecast the on- and off-target behavior of CRISPR tools that target RNA rather than DNA. To manage the expression of human genes in various ways, the study combines a deep learning model with CRISPR screens—for example, by flipping a switch to fully turn them off or turning [..]

A high-resolution inelastic neutron scattering technique for examining nanosecond dynamics is neutron spin echo spectroscopy. It advances knowledge of viscoelasticity and is particularly suited to studying atomistic motion in polymer systems. Doppler scattering must be taken into account, nevertheless, for samples that are moving or that are being subjected to shear. Researchers discover remarkable agreement [..]

For medical practitioners, medical imaging, such as X-rays, CT scans, MRIs, and ultrasounds, gives distinctive viewpoints. By locating biomolecules inside specimens, spectroscopy gives more information. The goal of the research is to enhance diagnostic imaging. The researchers are creating imaging devices that use terahertz radiation after realizing the advantages of imaging and spectroscopy. Terahertz radiation [..]