Microscopy Method, VR Enhance Cell Structure Analysis

A team of researchers from Carnegie Mellon University (Pittsburgh, PA) and the Benaroya Research Institute at Virginia Mason (BRI; Seattle, WA) has combined a nanoscale microscopy method called expansion microscopy with virtual reality (VR) to enable enlarging, exploring, and analyzing cell structures beyond the capabilities of traditional light microscopy. The development aims to accelerate researchers’ [..]

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Photopharmacology For Light-Controlled Drugs, Therapies

The emerging field of photopharmacology aims to use light as an external stimulus to activate drug molecules, and do so with a high degree of control over the time and place where this happens – a conceptually straightforward task, which in fact requires an interdisciplinary effort across both chemical synthesis and light delivery technology. Unlike [..]

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Laser Method For Detecting Trace Chemicals In Air

Researchers have developed a new laser method that can detect electric charges and chemicals of interest with unprecedented sensitivity. The new approach could one day offer a way to scan large areas for radioactive material or hazardous chemicals for safety and security applications. The new laser method, called mid-infrared picosecond laser-driven electron avalanche, detects extremely [..]

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Tweaking the design of microring sensors enhances their sensitivity without adding more implementation complexity. Optical sensing is one of the most important applications of light science. It plays crucial roles in astronomy, environmental science, industry, and medical diagnoses. Despite the variety of schemes used for optical sensing, they all share the same principle: The quantity [..]

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Lidar, particularly for the autonomous-vehicle revolution, is one of the hottest of hot topics today in optics and photonics. But what kind of lidar? The technology’s deceptively simple five-letter name packs in a complex array of choices, from spinning car-top sensors to tiny solid-state lidar scanners largely still on the drawing boards. In an invited [..]

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Researchers at the University of Innsbruck have demonstrated a method for measuring visible light particles nondestructively. The method could be used to investigate the quantum properties of light. The team placed an ionized calcium atom between two hollow mirrors, creating a cavity through which visible laser light was guided. “The ion has only a weak [..]

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After decades of patient scientific groundwork, the notion of “quantum computing” has, in the past several years, seen a surge in new activity and interest—not only in the lab, but at commercial firms like Google, Microsoft and IBM, and even among the public at large. Spurring that new interest have been successful lab demonstrations of [..]

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With a goal to reduce the mortality rate from sepsis by more than 70%, a team of European scientists has developed a microarray detector that uses a tiny blood sample to produce results in less than 30 minutes. Current techniques for detecting sepsis can take hours or even days to produce the results and diagnosis. [..]

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A team at the Institute of Scientific and Industrial Research at Osaka University has determined the optical parameters of cellulose molecules with exceptional precision.1 They found that cellulose’s intrinsic optical birefringence is high enough to be used in optical displays, such as flexible liquid crystal display (LCD) screens or electronic paper. Cellulose, a naturally occurring [..]

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Researchers have used 3D printing to make an inexpensive and portable high-resolution microscope that is small and robust enough to use in the field or at the bedside. The high-resolution 3D images provided by the instrument could potentially be used to detect diabetes, sickle cell disease, malaria and other diseases. “This new microscope doesn’t require [..]

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Researchers have shown that existing optical fibre technology could be used to produce microscopic 3-D images of tissue inside the body, paving the way towards 3-D optical biopsies. Unlike normal biopsies where tissue is harvested and sent off to a lab for analysis, optical biopsies enable clinicians to examine living tissue within the body in [..]

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Ovarian cancer is usually diagnosed only after it has reached an advanced stage, with many tumors spread throughout the abdomen. Most patients undergo surgery to remove as many of these tumors as possible, but because some are so small and widespread, it is difficult to eradicate all of them. Researchers at MIT, working with surgeons [..]

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Researchers at the California Institute of Technology (Caltech) Optical Imaging Laboratory (Pasadena, CA) have developed a technique for in vivo superresolution photoacoustic computed tomography (PACT) that breaks the acoustic diffraction limit by localizing the centers of single dyed droplets flowing in blood vessels. This technique has been shown to resolve brain blood vessels at a [..]

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Lensless microscopy with X-rays, or coherent diffractive imaging, is a promising approach. It allows researchers to analyse complex three-dimensional structures, which frequently exist in nature, from a dynamic perspective. Whilst two-dimensional images can already be generated quickly and in an efficient manner, creating 3D images still presents a challenge. Generally, three-dimensional images of an object [..]

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Biotechnologists, physicists, and medical researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have developed technology for microscopic imaging in living organisms. A miniaturised multi-photon microscope, which could be used in an endoscope in future, excites the body’s own molecules to illuminate and enables cells and tissue structures to be imaged without the use of synthetic contrast agents. The [..]

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Scientists at the U.S. Naval Research Laboratory (NRL) discovered a new method to passivate defects in next generation optical materials to improve optical quality and enable the miniaturization of light emitting diodes and other optical elements. “From a chemistry standpoint, we have discovered a new photocatalytic reaction using laser light and water molecules, which is [..]

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Engineers at the University of Wisconsin-Madison have developed a compact, single-shot, free-space-coupled spectrometer with hyperspectral imaging capabilities that can be integrated with a cellphone. The spectrometer is fabricated on top of and integrated with a CMOS chip. The miniaturized device measures 200 μm on each side and can lie directly on a sensor from a [..]

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Researchers in Switzerland and Australia have brought together the physics of dielectric metasurfaces and hyperspectral imaging to create an ultrasensitive, label-free biosensing platform (Nat. Photon., doi: 10.1038/s41566-019-0394-6). The team believes that the platform—reportedly capable of detecting and analyzing samples at spatial concentrations of less than three molecules per square micron—could ultimately enable compact portable diagnostics [..]

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For autonomous vehicles, lidar is an essential technology to recognize and detect surrounding objects. Researchers at KTH have taken aim at the key component of lidar, optical beam-stearing, and developed a device that is significantly cheaper to manufacture, lighter and more resource-efficient than previous variations of the technology. This advance could pave the way for [..]

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Thanks to a microscopy method, a team of researchers at the Pasteur Institute (Paris, France) and the French National Institute of Health and Medical Research (INSERM; also in Paris) has revealed that chimeric antigen receptor (CAR) T cells can induce tumor regression by directly targeting and killing cancer cells, uncovering new details of how these [..]

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